All inquiries regarding this data set should be directed towards the following contact persons:

• Iben Lyskjær Heimann
• Christina Espeseth Grand
• Laura Elgaard Iisager Jensen

Study description¶

TCRβ-sequencing was performed on buffy-coat-derived DNA from 232 renal cell carcinoma patients (132 discovery and 100 independent validation samples). Samples were collected from the Bio- and Genome Bank, Denmark (RBGB) during 2011 and 2020. Libraries were prepared from up to 3,000-5,000 ng of DNA using the Cellecta DriverMap AIR TCR-BCR Profiling Kit (Human DNA) and sequenced paired-end on an Illumina NovaSeq 6000 using S1, S2, or S4 flow cells. Base call files were converted to fastq and demultiplexed by index sequence using bcl2fastq. Data contains fastq files.

Original publication¶

Grand, C. E., et al. Preoperative Peripheral T-cell Receptor β Repertoire Diversity and Overall Survival for Localized Renal Cell Carcinoma

Data access¶

External researchers (academic or commercial) interested in analysing the dataset will need to contact the Data Access Committee via email to iben.lyskjar@clin.au.dk. The Data Access Committee is formed of Iben Lyskjær and Ole Halfdan Larsen (Department of Clinical Medicine, Aarhus University). Due to Danish Law, for the authors to be allowed to share the data (pseudonymised) it will require prior approval from The Danish National Committee on Health Research Ethics (or similar) for the specific new research goal. The author (based in Denmark) has to submit the application for ethical approval, with the external researcher(s) as named collaborator(s). In addition to ethical approval, a Collaboration Agreement and a Data Processing Agreement is required, both of which must be approved by the legal office of the institution of the author (data owner) and the legal office of the institution of the external researcher (data processor).